165 - 342 http://localhost:8080/xmlui/handle/123456789/7126 2026-04-14T20:56:13Z 2026-04-14T20:56:13Z Khan, Zakir Karatas, Yusuf http://localhost:8080/xmlui/handle/123456789/7206 2024-11-01T03:42:29Z 2022-01-01T00:00:00Z

Title: Adverse drug reaction reporting for more than a decade: The need for pharmacovigilance policy implementation in Turkey Authors: Khan, Zakir; Karatas, Yusuf

2022-01-01T00:00:00Z Chelvaraj, Radtthiga Thamotaran, Tinesh Yee, Cheong M. Fong, Chong M. Zhe, Ngoo Q. Azhany, Yaakub http://localhost:8080/xmlui/handle/123456789/7204 2024-11-01T03:40:13Z 2022-01-01T00:00:00Z

Title: The invasive Klebsiella pneumoniae syndrome: Case series Authors: Chelvaraj, Radtthiga; Thamotaran, Tinesh; Yee, Cheong M.; Fong, Chong M.; Zhe, Ngoo Q.; Azhany, Yaakub Abstract: This case-series aims to report three cases of endogenous endophthalmitis due to invasive Klebsiella pneumoniae syndrome. Case 1: A 34-year-old lady who was admitted for pneumonia developed painful blurring of vision and redness in the right eye (RE) for one week. An examination of the RE revealed visual acuity (VA) of light perception (PL) with positive relative afferent pupillary defect (RAPD), proptosis, and restriction of extraocular movement with hypopyon. The patient was treated for RE panophthalmitis with a lung abscess and was started on systemic and topical antibiotics. The vitreous tap culture grew Klebsiella pneumoniae. Despite treatment, the patient’s condition deteriorated, and evisceration was undertaken. Case 2: A 38-year-old lady presented with a acute onset of RE pain associated with blurred vision and redness for two days, and fever for one week. RE VA was hand movement with a positive RAPD and anterior chamber cells of 2þ. A B-scan revealed a dome-shaped subretinal mass with exudative retinal detachment. The patient was treated for RE panophthalmitis complicated by a basal ganglia abscess. The urine and vitreous tap cultures grew Klebsiella pneumoniae. She responded to high-dose intravenous and intravitreal antibiotics. Unfortunately, her RE became phthisical. Case 3: A 70-year-old lady presented with painless blurring of vision over the RE. The blood and urine cultures grew Klebsiella pneumoniae. RE VA was PL, and she was treated for endogenous endophthalmitis. The vitreous culture grew Klebsiella pneumoniae. Unfortunately, the RE became phthisical.

2022-01-01T00:00:00Z Rahman, Kurnia H. Surboyo, Meircurius D.C. Radithia, Desiana Parmadiati, Adiastuti E. Wihandono, Asdi Ernawati, Diah S. http://localhost:8080/xmlui/handle/123456789/7203 2024-11-01T03:36:36Z 2022-01-01T00:00:00Z

Title: Oral squamous cell carcinoma with essential thrombocythemia and positive JAK2 (V617F) mutation Authors: Rahman, Kurnia H.; Surboyo, Meircurius D.C.; Radithia, Desiana; Parmadiati, Adiastuti E.; Wihandono, Asdi; Ernawati, Diah S. Abstract: Essential thrombocythemia is a condition caused by a high platelet count and a positive JAK2 (V617F) mutation. There is an increasing occurrence of malignancy, such as oral squamous cell carcinoma (OSCC), in patients with essential thrombocythemia. The objective of this case report is to document the novel instance of a patient with OSCC after being diagnosed with essential thrombocythemia and a positive JAK2 (V617F) mutation. The patient was a 42-year-old female who complained of an ulcer and pain in the dextral lateral tongue for three months. After two weeks, the pain diminished; however, there was swelling and tenderness on the ulcer. The patient was diagnosed with essential thrombocythemia and a positive JAK2 (V617F) mutation and began undergoing hydroxyurea therapy three months prior to the OSCC diagnosis. The diagnosis of OSCC was based on exfoliative cytology and MRI. The patient was treated with an antiseptic mouthwash to prevent secondary infection and referred to an oncologist to manage the OSCC. It is possible to use the suspected markers of thrombocytosis and a positive JAK2 (V617F) mutation to define the OSCC diagnosis.

2022-01-01T00:00:00Z Grillo, Ricardo Borba, Alexandre M. Lima, Ana Paula C.B. Pitta, Marcos C. Veronesi, Regiane Jodas, Claudio R.P. http://localhost:8080/xmlui/handle/123456789/7201 2024-11-01T03:34:21Z 2022-01-01T00:00:00Z

Title: Use of non-surgical aesthetic refinement after orthognathic surgery: Case studies Authors: Grillo, Ricardo; Borba, Alexandre M.; Lima, Ana Paula C.B.; Pitta, Marcos C.; Veronesi, Regiane; Jodas, Claudio R.P. Abstract: Orthognathic surgery has an undeniable functional effect, but the aesthetic result must not be disregarded, especially since many patients visit the surgeon precisely because of an aesthetic complaint and ignore the practical benefits. The aim of this paper is to discuss about an ideal treatment that combines this functional improvement with facial aesthetics and improves it after the operation. In order to predict which aesthetic deficits may occur, a facial analysis is essential. As precise as the virtual planning may be, there is still no exact predictability of soft tissue behavior. Some non-surgical procedures can help the surgeon achieve a result that better meets the patients’ expectations. Imaging exams, photographs, facial analyzes, and patient complaints are essential to assess the possibility of any postoperative refinement. The entire surgical planning is discussed with the patient; the possibility of refinement must be part of the treatment plan. The surgeon’s focus is on the functional correction of the dentofacial deformity, but the aesthetic outcome is essential for the patient. The results of this study suggest that refinement should be part of the treatment plan.

2022-01-01T00:00:00Z