Vol. 16 No. 1 - Vol. 20 No. 4 http://localhost:8080/xmlui/handle/123456789/6729 2026-04-08T21:19:48Z 2026-04-08T21:19:48Z Kareem, Nawar R. Mosa, Amal U. juhiashi, Atheer M. Rashid Al http://localhost:8080/xmlui/handle/123456789/11909 2025-07-16T03:05:10Z 2025-01-01T00:00:00Z

Title: Impact of CYP2A6 genetic polymorphism on letrozole efficacy in Iraqi women with polycystic ovary syndrome Authors: Kareem, Nawar R.; Mosa, Amal U.; juhiashi, Atheer M. Rashid Al Abstract: Objectives: This study investigated the effects of a genetic polymorphism in CYP2A6 (CYP2A6*2, 1799T>A) on the therapeutic response to letrozole in Iraqi women with polycystic ovarian syndrome (PCOS)-induced infertility. Methods: A prospective, single-center, randomized, controlled pragmatic clinical trial was conducted in 94 Iraqi women with PCOS-induced infertility. The ovulation response to letrozole (2.5 mg/day for 5 days) was assessed via ultrasound (follicle size 18 mm) and hormonal assays (follicle-stimulating hormone, luteinizing hormone, estradiol, prolactin, testosterone, and anti- Mu¨ llerian hormone). Genotyping of CYP2A6*2 (1799T>A, rs1801272) was performed using allelespecific PCR on blood-derived DNA, and the distribution of wild-type (AA), heterozygous (AT), and mutant (TT) alleles was recorded. The association between genotype and letrozole efficacy, including follicle size, endometrial thickness, sex hormone levels, and pregnancy incidence, was also evaluated. Results: The wild-type allele (AA) of the CYP2A6*2 gene (1799A>T, rs1801272) was widely distributed in approximately 51 (54.26 %) women with PCOS. Heterozygous alleles (AT) and mutant alleles (TT) were present in 2 (2.13 %) and 41 (43.61 %) women with PCOS, respectively. There was no notable difference between infertile women who did or did not respond to letrozole and those who carried different genotypes (wildtype AA, heterozygous AT, and mutant TT) of CYP2A6 (1799T>A) regarding sex hormones, follicle size, endometrial thickness, or incidence of gestation (P > 0.05). Conclusion: The CYP2A62 (1799T>A) genetic variant was not associated with letrozole efficacy or resistance in Iraqi women with PCOS, suggesting that this polymorphism does not significantly influence therapeutic outcomes.

2025-01-01T00:00:00Z Okesanya, Olalekan John Ahmed, Mohamed Mustaf Adebayo, Uthman Okikiola dkk. http://localhost:8080/xmlui/handle/123456789/11906 2025-07-16T03:03:27Z 2025-01-01T00:00:00Z

Title: First documented human case of mpox: Implications for global surveillance, public health and policy Authors: Okesanya, Olalekan John; Ahmed, Mohamed Mustaf; Adebayo, Uthman Okikiola; dkk.

2025-01-01T00:00:00Z Okesanya, Olalekan John Adebayo, Uthman Okikiola Ahmed, Mohamed Mustaf dkk. http://localhost:8080/xmlui/handle/123456789/11903 2025-07-16T03:02:03Z 2025-01-01T00:00:00Z

Title: Towards a resilient, pandemic-prepared, and equitable future: Public health and policy perspectives on the world health assembly agreement Authors: Okesanya, Olalekan John; Adebayo, Uthman Okikiola; Ahmed, Mohamed Mustaf; dkk.

2025-01-01T00:00:00Z A’aqoulah, Ashraf Metwally, Ashraf A. El Khateeb, Bader Al dkk. http://localhost:8080/xmlui/handle/123456789/11901 2025-07-16T03:00:40Z 2025-01-01T00:00:00Z

Title: Challenges and opportunities of complexity theory in health care systems Authors: A’aqoulah, Ashraf; Metwally, Ashraf A. El; Khateeb, Bader Al; dkk. Abstract: Recent studies of health and complexity have proposed a new definition of health that encompasses the systematic nature of health in order to depict its inherent complexity. The interaction between a clinician and patient has many of the characteristics of a complex adaptive system. The complex nature of primary health care systems, the complexity of real-time data analytics in health care using information systems, and complexity related to the prescription of drugs further reflect the complexity of health care systems. These characteristics indicate that it is necessary to transform health care from an egocentric system to an ecocentric system by using a complex network electronic knowledge research model that provides community engagement in decision making for health improvement and involves adaptive leadership implementing different strategies for solving complex problems. Indeed, it is essential to use a transdisciplinary approach to redesign the health system by developing effective monitoring and evaluation systems inside health systems to ensure patient safety and information transparency, and the effective use of information technology to improve the quality of the services delivered.

2025-01-01T00:00:00Z