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Association between rs2787094 Genetic Variants in ADAM33 Gene and Asthma in Indonesian Population: Preliminary Study

2024-09-26T14:57:59Z

Title: Association between rs2787094 Genetic Variants in ADAM33 Gene and Asthma in Indonesian Population: Preliminary Study Authors: Viyati, Kencono; Prayuni, Kinasih; Zulhamida, Yenni; Razari, Intan; Yuliwulandari, Rika Abstract: Background: Asthma is a multifactorial disease that encompasses a multitude of genetic and environmental factors. One such factor is the disintegrin and metalloprotein-33 (ADAM33) gene, which is correlated with asthma and bronchial hyperresponsiveness. Previous studies conducted on Asian populations have reported a significant association between rs2787094 polymorphism in the ADAM33 gene and asthma. Methods: Our study involved 153 Indonesian participants. TaqMan genotyping assay was used to analyze rs2787094 polymorphism in the ADAM33 gene. Results: No significant association was detected between the allele and genotype frequencies of rs2787094 and asthma in the case and control subjects (p = 1.00). The distribution of rs2787094 genotypes in healthy controls was CC (12.1%), CG (42.1%), and GG (45.8%). The genotype distribution in Indonesians was similar to East Asians in 1,000 genomes dataset. Conclusions: This is the first study to investigate the association between rs2787094 polymorphism in the ADAM33 gene and asthma in the Indonesian population and concluded that it is not associated. Future studies with larger sample sizes and more single nucleotide polymorphisms in the ADAM33 gene are needed to validate these results.

Relationship Between Plasma Fluoride Levels, Glutathione Peroxidase Activity, Hemoglobin, and Abortion in Rural and Urban Pregnant Women from Settat (Morocco)

2024-09-26T14:53:03Z

Title: Relationship Between Plasma Fluoride Levels, Glutathione Peroxidase Activity, Hemoglobin, and Abortion in Rural and Urban Pregnant Women from Settat (Morocco) Authors: Masnaoui, Lalla Asmaa Katir; Katir, Lalla Asmaa; Bouchab, Habiba Abstract: Abstract Background: This study aimed to investigate the relationship between plasma fluoride levels, glutathione peroxidase activity, hemoglobin, and abortion among rural and urban pregnant women from Settat province (Morocco). Methods: Blood samples were collected from rural pregnant women who had not undergone abortion (N = 224), rural pregnant women who had an abortion (N = 38), urban pregnant women who had not undergone abortion (N = 163), and urban pregnant women who had an abortion (N = 14). Results: The highest (p < 0.01) plasma fluoride levels and the lowest (p < 0.01) GPx activity were observed in rural pregnant women. In all participants, plasma fluoride levels were significantly higher (p < 0.001), and the GPx activity was significantly (p < 0.001) lower in pregnant women who had an abortion compared with those who did not undergo such process. No significant difference was observed between the hemoglobin levels of all participants. Furthermore, abortion was positively correlated with plasma fluoride levels (p < 0.001) and negatively correlated with GPx activity (p < 0.001) in rural participants. Conclusions: Rural pregnant women had higher plasma fluoride levels and lower GPx activity, which correlated with the increased abortion risk and oxidative stress.

Prediction of Factors for Patients with Hypertension and Dyslipidemia Using Multilayer Feedforward Neural Networks and Ordered Logistic Regression Analysis: A Robust Hybrid Methodology

2024-09-26T14:35:33Z

Title: Prediction of Factors for Patients with Hypertension and Dyslipidemia Using Multilayer Feedforward Neural Networks and Ordered Logistic Regression Analysis: A Robust Hybrid Methodology Authors: Ahmad, Wan Muhamad Amir W; Adnan, Mohamad Nasarudin Bin; Yusop, Norhayati; dkk. Abstract: Background: Hypertension is characterized by abnormally high arterial blood pressure and is a public health problem with a high prevalence of 20%–30% worldwide. This research combined multiple logistic regression (MLR) and multilayer feedforward neural networks to construct and validate a model for evaluating the factors linked with hypertension in patients with dyslipidemia. Methods: A total of 1000 data entries from Hospital Universiti Sains Malaysia and advanced computational statistical modeling methodologies were used to evaluate seven traits associated with hypertension. R-Studio software was utilized. Each sample's statistics were calculated using a hybrid model that included bootstrapping. Results: Variable validation was performed by using the well-established bootstrap-integrated MLR technique. All variables affected the hazard ratio as follows: total cholesterol (β1: −0.00664; p < 0.25), diabetes status (β2: 0.62332; p < 0.25), diastolic reading (β3: 0.08160; p < 0.25), height measurement (β4: −0.05411; p < 0.25), coronary heart disease incidence (β5: 1.42544; p < 0.25), triglyceride reading (β6: 0.00616; p < 0.25), and waist reading (β7: −0.00158; p < 0.25). Conclusions: A hybrid approach was developed and extensively tested. The hybrid technique is superior to other standalone techniques and allows an improved understanding of the influence of variables on outcomes.

Risk Factors Associated with Occupational Stress among Malaysian Construction Professionals

2024-09-26T14:14:36Z

Title: Risk Factors Associated with Occupational Stress among Malaysian Construction Professionals Authors: Fauzan, Nur Syafiqah; Tajuddin, Nur Alia Farahanin Mohd; Thanarajee, Neroshini Abstract: Background: Construction industries that focus on project-based nature, pressure, and long hours may lead to job-related stress among workers. In many emerging nations, robust economic growth plans generate occupational depression, anxiety, and stress among construction industry personnel. This study aims to determine the relationship between these items and the risk factors (demographic) among Malaysian construction professionals. Methods: A cross-sectional study was carried out among 173 Malaysian construction professionals. A DASS-21 questionnaire is used to survey eligible respondents. Results: Findings show that construction professionals have a high level of stress (54.9%), anxiety (48.5%), and depression (37%). Gender is significantly associated with stress (p = 0.000) and depression (p = 0.000). In turn, stress (p = 0.038), anxiety (p = 0.000), and depression (p = 0.001) all demonstrate a significant relationship with health status Conclusions: Health status is the risk factor most significantly associated with occupational stress. Given the findings, construction managers can help protect their employees and their mental health by promoting a healthy workplace through stress management and social activities.