DSpace Collection: 1 - 64

Split cornea transplantation in anterior lamellar keratoplasty for limbal dermoid surgery: a case report

2024-09-20T07:53:57Z

Title: Split cornea transplantation in anterior lamellar keratoplasty for limbal dermoid surgery: a case report Authors: Retno Kurniawardhani, Dewinta; Widyawati, Syska; Rhendy, Rio; Kodrat, Evelina Abstract: Split cornea transplantation in anterior lamellar keratoplasty for limbal dermoid surgery: a case report Dewinta Retno Kurniawardhani1 , Syska Widyawati1 , Rio Rhendy1 , Evelina Kodrat2 Medical Journal of Indonesia Case Report/Series ABSTRACT Limbal dermoid is a rare congenital lesion that can impair vision and raise aesthetic concerns. Surgery is frequently required to reduce discomfort and enhance visual outcomes. A 20-year-old woman presented with a limbal dermoid measuring 4.5 mm in diameter and half the depth of the stroma. Excision was performed with anterior lamellar keratoplasty (ALK) using a post-Descemet's membrane endothelial keratoplasty graft, which resulted in signs of graft failure. Re-surgery was then performed with post-Descemet's stripping endothelial keratoplasty graft. It yielded a clear graft with good visual acuity. The first corneal graft utilized 95% of the graft thickness to cover 55% of the defect, leading to poor host-donor apposition. The second graft employed 55–65% to cover the same portion of the defect. The proportional thickness of the graft is crucial for a successful ALK. Split cornea transplantation produces respectable results; however, the corneal thickness must be carefully considered. KEYWORDS cornea transplantation, dermoid cyst, host-graft reaction, keratoplasty, lamellar

Association of perceived male sexual dysfunction and sexually transmitted disease to female sexual function among Indonesian women

2024-09-20T07:46:50Z

Title: Association of perceived male sexual dysfunction and sexually transmitted disease to female sexual function among Indonesian women Authors: Anara Manurung, Mega; Erlianti Rahardjo, Harrina Abstract: Association of perceived male sexual dysfunction and sexually transmitted disease to female sexual function among Indonesian women Mega Anara Manurung, Harrina Erlianti Rahardjo Medical Journal of Indonesia Clinical Research ABSTRACT BACKGROUND Male sexual dysfunction (MSD)’s impact on female partners is challenging to understand. Male erectile dysfunction (ED) and ejaculation disorder likely affect female sexual function. This study aimed to examine the prevalence of female sexual dysfunction and disorder as well as the relationship between perceived MSD and female sexual function using the validated Indonesian short version of the 6-item Female Sexual Function Index (FSFI-6). METHODS This cross-sectional study was conducted at Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from February 2018 to February 2019. About 702 Indonesian married women, including patients, visitors, and medical and nonmedical staff, provided the sociodemographic, FSFI-6, quality of life, and sexual function (ED, ejaculation disorder, and desire problems), and sexually transmitted disease (STD) data. The association between categorical variables was evaluated using Fisher’s test. Logistic regression was used for multivariate analysis, and a p-value of 0.05 was considered statistically significant. RESULTS Among 702 women, about 242 had sexual dysfunction (34.5%), 20 had sexual disorder (2.8%), 172 had low desire (24.5%), 72 had low arousal (10.3%), 253 had orgasmic function (36.0%), and 575 had sexual pain (81.9%). The respondents reported their partners’ STD, desire problems, ED, and ejaculation disorder. Female sexual disorder and low desire were associated with perceived ED. Female sexual disorder was associated with STD (Wald = 10.3, p = 0.001) and desire problems (Wald = 6.89, p = 0.008). No other MSD was associated with female sexual function. CONCLUSIONS Perceived STD and male desire problems affected female sexual disorder. KEYWORDS sexual arousal, sexual behavior, sexual health

Comparative efficacy of intravenous levetiracetam and phenytoin in status epilepticus: a systematic review and meta-analysis of randomized controlled trials

2024-09-20T07:43:37Z

Title: Comparative efficacy of intravenous levetiracetam and phenytoin in status epilepticus: a systematic review and meta-analysis of randomized controlled trials Authors: Anis Tasya, Galuh; Iriani Djatmiko, Nadhira; Haidar Fazlur Rahman, Farhan; Kusuma Rahmawat, Vita Abstract: Comparative efficacy of intravenous levetiracetam and phenytoin in status epilepticus: a systematic review and meta-analysis of randomized controlled trials Galuh Anis Tasya1 , Nadhira Iriani Djatmiko1 , Farhan Haidar Fazlur Rahman1 , Vita Kusuma Rahmawati2 Clinical Research ABSTRACT BACKGROUND Status epilepticus (SE) is a neurological emergency, with the current guidelines for second-line anticonvulsants may include phenytoin, levetiracetam, valproic acid, and phenobarbital. However, some studies suggest that levetiracetam may be better at stopping seizures in SE. This study aimed to compare the efficacy of intravenous (IV) levetiracetam and phenytoin in SE. METHODS We searched PubMed, ScienceDirect, Cochrane, and Google Scholar for randomized controlled trials (RCTs) on administering IV levetiracetam or phenytoin in patients with SE. RCTs were screened using eligibility criteria, and their quality was assessed using the Cochrane risk of bias tool. Heterogeneity was assessed using the I² test, and publication bias was evaluated using Egger’s test. All analyses were performed using Review Manager version 5.4 (The Cochrane Collaboration, UK) and Stata 17 (StataCorp LLC, USA). RESULTS 12 RCTs involving 2,137 patients (1,099 receiving levetiracetam) met the inclusion criteria. Pooled analysis showed that levetiracetam therapy had a significantly higher rate of seizure cessation than phenytoin (RR: 1.10, 95% CI = 1.05−1.14, p = 0.02, I² = 51%). Less adverse events were observed in the levetiracetam group (9.34%) than in the phenytoin group (11.62%; RR: 0.82, 95% CI = 0.66–1.02, p = 0.07). However, there was no significant difference regarding IV levetiracetam or phenytoin administration with the incidence of admission to critical care (RR: 1.01; 95% CI = 0.93–1.10, p = 0.80) and mortality (RR: 1.08; 95% CI = 0.54–2.15; p = 0.82). CONCLUSIONS IV levetiracetam was significantly better in the cessation of seizures in SE patients than phenytoin. KEYWORDS levetiracetam, phenytoin, status epilepticus

Factors associated with the uncorrectable congenital heart disease in children with pulmonary arterial hypertension

2024-09-20T07:38:30Z

Title: Factors associated with the uncorrectable congenital heart disease in children with pulmonary arterial hypertension Authors: Handoyo, Handoyo; Gunawijaya, Eka; Veny Kartika Yantie, Ni Putu Abstract: Factors associated with the uncorrectable congenital heart disease in children with pulmonary arterial hypertension Handoyo, Eka Gunawijaya, Ni Putu Veny Kartika Yantie Medical Journal of Indonesia Clinical Research ABSTRACT BACKGROUND Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) is a common complication of uncorrected left-to-right shunt defects in acyanotic CHD and a frequent type of pulmonary hypertension in youth. The standards for operability in left-to-right shunts with increased pulmonary vascular resistance are not universally agreed upon. This study aimed to identify variables associated with uncorrectable lesion in children with PAH-CHD. METHODS This retrospective study used a database of all children who underwent cardiac catheterization at Sanglah Hospital, Bali, from May 2009 to April 2021. Pulmonary hypertension was defined as pulmonary artery pressure of >25 mmHg, while correctability was a fall of >20% in the pulmonary arterial resistance index (PARI) with final value of <6 WU/m2 when doing an acute vasoreactivity test using 100% oxygen. The analyses were carried out using SPSS software version 22.0 (IBM Corp., USA). RESULTS A total of 104 children were included. Cardiac catheterization showed that the uncorrectable group had a higher PARI (14.4 [8.88] WU/m2 versus 8.43 [3.85] WU/m2 ) and lower flow ratio (1.27 [0.83] versus 1.47 [0.77]) at baseline. In terms of correctability, pre-tricuspid lesions (OR = 0.05; 95% CI = 0.01–0.47; p = 0.01) and younger age group (OR = 0.32; 95% CI = 0.12–0.85; p = 0.01) were protective variables, whilst high baseline PARI (OR = 4.54; 95% CI = 1.64–12.57; p = 0.01) was unfavorable. CONCLUSIONS High baseline PARI was the most significant variable in predicting uncorrectable left-to-right shunt defects in PAH-CHD. KEYWORDS children, congenital heart disease, heart septal defects, pulmonary hypertension