http://localhost:8080/xmlui/handle/123456789/4118 2026-04-14T20:48:58Z 2026-04-14T20:48:58Z Ratsmita, Firly Ilyas, Muhammad http://localhost:8080/xmlui/handle/123456789/4124 2023-03-02T08:09:57Z 2021-01-01T00:00:00Z

Title: BIOMONITORING OF SEVOFLURANE EXPOSURE IN ANESTHESIOLOGIST Authors: Ratsmita, Firly; Ilyas, Muhammad Abstract: BIOMONITORING OF SEVOFLURANE EXPOSURE IN ANESTHESIOLOGIST Firly Ratsmita 1 Muhammad Ilyas 2 1 Departement of Community Medicine, Medical Faculty,University of Indonesia, Indonesia 2 Occupational Environmental Health and Research Center IMERI FKUI, Indonesia Correspondence Address: Firly Ratsmita Email: firly.ratsmita@ui.ac.id ABSTRACT Sevoflurane is used by anesthetists for the induction and maintenance of general anesthesia. This causes the anesthetist to get daily exposures. This will be a potential hazard for exposed operating room personnel, especially anesthetists. The adverse health effects of sevoflurane as hepatotoxic, nephrotoxic and neurotoxic in the human body can be a risk for anaesthetists. Biological monitoring can be done by measuring the levels of sevoflurane and its metabolites or by looking at biomarkers for their effects on health effects. The aim of this study was to seek a literature review on the biomonitoring of sevoflurane exposure in anaesthetists. We searched the literature review using the PRISMA method in PubMed and Google scholar using the following keywords "occupational disease" "chronic effects" "anaesthetist" "sevoflurane exposure" "inorganic fluoride" "biomarkers" previously using the term MeSH and combined with Boolen "OR" and AND". We obtain 75 articles taken from the database, excluded 35 articles, and selected 5 articles. The results of the review articles showed that there were health effects, especially on liver and kidney function in chronic exposure. Biological monitoring can be undertaken by detecting sevoflurane and its metabolites in the urine during work and function of the liver and kidneys. The evidence for biological monitoring as surveillance in anaesthesiologists remain inconsistent due to limited studies. We recommend to measure sevoflurane in ambient air using a hierarchy of controls, such as elimination, replacement, engineering, administrative and personal protective equipment. We need to undertaken environmental and biological monitoring in order to acquire a safe and healthy work environment. Keywords: sevoflurane exposure, occupational health, anesthesiologist

2021-01-01T00:00:00Z Nasriawati, Anna Ilyas, Muhammad S.Widyahening, Indah http://localhost:8080/xmlui/handle/123456789/4123 2023-03-02T08:06:18Z 2021-01-01T00:00:00Z

Title: LUNG CANCER ASSOCIATED WITH CARBON BLACK EXPOSURE ON BRICK WORKERS Authors: Nasriawati, Anna; Ilyas, Muhammad; S.Widyahening, Indah Abstract: LUNG CANCER ASSOCIATED WITH CARBON BLACK EXPOSURE ON BRICK WORKERS Evidence-Based Case Report Anna Nasriawati 1 , Muhammad Ilyas 2 , Indah S.Widyahening 3 1 Occupational Medicine Specialist Program, Faculty of Medicine, Universitas Indonesia, Indonesia 2,3 Department of Community Medicine, Universitas Indonesia, Indonesia Correspondence Address: Anna Nasriawati Email annatroys@gmail.com ABSTRACT Carbon black aerosol has potential risks to human health. It has been acknowledged to cause cardiovascular and respiratory diseases in humans. International Agency for Research on Cancer (IARC) 2010 stated that carbon black classification is 2b, which is carcinogenic. This research explains a case of lung cancer due to carbon black exposure and reviews the literature of occupational cases to get the answers about the effects of carbon black exposure and the increasing risk of lung cancer for workers exposed to carbon black. The literature review was performed to answer the clinical question via electronic databases: PubMed and Google Scholar. The keywords used were ‘carbon black’ and ‘lung cancer’ and 'workers'. The inclusion criteria of this searching strategy were the workers which exposed to carbon black, meta-analysis, randomized controlled trial, systematic reviews, cohort. The exclusion criteria of this article were inaccessible articles, RCTs that have been used in the recent systematic reviews. The selected articles were then critically appraised using relevant criteria by the Oxford Center for Evidence-based Medicine. This study reviews the literature by Rota Matteo; The epidemiological evidence on the polyaromatic hydrocarbon (PAH) high exposed, perspective cohort study by Delli LD, and the control case study by Marie EPt. All the researches above showed that carbon black carcinogenic potential is the same as the IARC monograph statement that the epidemiological studies of carbon black provide possible carcinogenicity (Group of 2B). Keywords: carbon black, lung cancer, workers

2021-01-01T00:00:00Z Christa Monintja, Keyne Ilyas, Muhammad http://localhost:8080/xmlui/handle/123456789/4122 2023-03-02T08:02:33Z 2021-01-01T00:00:00Z

Title: BONE ALUMINUM AS A BIOLOGICAL MONITORING OF OCCUPATIONAL EXPOSURE TO ALUMINUM Authors: Christa Monintja, Keyne; Ilyas, Muhammad Abstract: BONE ALUMINUM AS A BIOLOGICAL MONITORING OF OCCUPATIONAL EXPOSURE TO ALUMINUM Keyne Christa Monintja 1 and Muhammad Ilyas 2 1 Occupational Medicine Specialty Programme, Faculty of Medicine, Universitas Indonesia, Indonesia 2 Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia Correspondence address: Keyne Christa Monintja Email: keynechrista@gmail.com ABSTRACT The current proposed biological monitoring of aluminum is based on the analysis of aluminum concentration in blood/serum or in urine, but both considered to be reflective of short-term exposure. Based on its toxic kinetics, aluminum has been demonstrated to be accumulated in the bone. The aim of this study is to find out whether by analyzing bone aluminum, we might have an overview of aluminum accumulation that might cause health problems in the future. This review was conducted through a method of search and selection of articles from Pubmed, Cochrane Library, and Google Scholar databases aimed to answer question rising from the problem statement of this study. The process of searching articles used the keywords “occupational aluminum” OR “bone aluminum” AND “biological monitoring” OR “biomonitoring”. The selection of articles was performed using the defined inclusion and exclusion criteria. Initially, 61 articles were obtained, but after the selection process and hand searching, four articles remained consisting of two case reports and two cross sectional studies. Based on the selected evidence-based resources, bone can be a promising potential biomarker of aluminum, especially for cumulative exposure assessment. The use of in vivo neutron activation analysis (IVNAA) or X-ray fluorescence (XRF) technology for the purpose of noninvasively quantifying aluminum concentration in the bone, is suitable enough to be performed in occupational settings. Keywords: Bone aluminum, occupational exposure, IVNAA, XRF, biomonitoring, biological monitoring

2021-01-01T00:00:00Z Ilyas, Muhammad Sumaryani Soemarko, Dewi Yunia Fitria, Dewi Purwito Adi, Nuri Isbayu Putra, Marsen Kualasari, Yessi http://localhost:8080/xmlui/handle/123456789/4121 2023-03-02T07:56:13Z 2021-01-01T00:00:00Z

Title: RELATIONSHIP BETWEEN NUTRITION INTAKE AND THE FITNESS OF MANUFACTURING WORKERS IN INDONESIA Authors: Ilyas, Muhammad; Sumaryani Soemarko, Dewi; Yunia Fitria, Dewi; Purwito Adi, Nuri; Isbayu Putra, Marsen; Kualasari, Yessi Abstract: RELATIONSHIP BETWEEN NUTRITION INTAKE AND THE FITNESS OF MANUFACTURING WORKERS IN INDONESIA Muhammad Ilyas 1,3 , Dewi Sumaryani Soemarko , Marsen Isbayu Putra 1,3 , Nuri Purwito Adi 1,3 , Dewi Yunia Fitria 1,3 1,3 , Yessi Kualasari 2 1 Department of Community Medicine, Faculty of Medicine, University of Indonesia, Indonesia 2 Ministry of Manpower of the Republic of Indonesia, Indonesia 3 Occupational Environmental Health and Research Center IMERI FKUI, Indonesia Alamat korespondensi: Muhammad Ilyas Email:muhammadilyas@ui.ac.id ABSTRACK Indonesia ranks fourth in the world out of 15 countries whose manufacturing industries contribute more than 10% to the Gross Domestic Product (GDP). Nowadays, one of the consequences of the rapid development of the manufacturing industry in Indonesia is related to work productivity. Each person's work productivity is not the same, one of them depends on the availability of nutrients in the body. Lack of nutritional consumption for someone from standard needs will affect health conditions, activities, and work productivity. Nutritional substances in workers also affect fitness in addition to other factors such as age, health status, nutritional status, nutritional status, gender, and psychological conditions. Based on the description above, it is necessary to study the relationship between nutritional status and physical fitness of workers in manufacturing companies in Indonesia. The study was cross sectional on 120 workers from 6 manufacturing companies in Indonesia which was conducted using cluster sampling. Assessment of individual characteristics was conducted by direct interview. Assessment of nutritional intake uses the Food Frequency Questionnaire (FFQ) and the results were categorized as appropriate and inappropriate based on the 2019 nutritional adequacy figure for the Indonesian population. The fitness assessment (physical capacity) used a six-minute walking test by an occupational specialist and was converted to Meters and categorized with a cut off of 4.5 Mets to be sufficient or insufficient. About one third of manufacturing workers were centrally obese. Characteristics The dietary intake according to the recommendation were only about 10%, namely the appropriate carbohydrate intake 11.7% (Frequency 8.46 times (533.22 gr)), suitable fat 12.5% (Frequency 2.75 times (57.14 gr)), and suitable protein 10% (Frequency 6.55 times (101.77 gr)). The physical capacity of manufacturing workers in Indonesia was categorized as sufficient as much as 75.8% of their workload. Factors that affect physical capacity, namely age ≥ 40 years have 4.37 times less physical capacity and protein intake affected physical capacity / fitness for workers (p = 0.02). About a third of manufacturing workers were centrally obese. The characteristic of food intake in accordance with the recommended nutritional adequacy of the Indonesian population was only about 10%. The physical capacity of manufacturing workers in Indonesia was categorized as sufficient as much as 75.8% of their workload. Factors that affected physical capacity were age and protein intake. Keywords: Food Intake, Food Frequency Questionnaire (FFQ), Manufacturing Worker, Fitness, Six-Minute Walking Test.

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