DSpace Collection:http://localhost:8080/xmlui/handle/123456789/20012026-04-08T19:27:07Z2026-04-08T19:27:07ZIdentification and Validation of LYZ and CCL19 as Prognostic Genes in the Cervical Cancer Micro-EnvironmentZhong, Peng-QiangYan, Xing-Xinghttp://localhost:8080/xmlui/handle/123456789/28722022-08-12T03:06:56Z2022-06-01T00:00:00ZTitle: Identification and Validation of LYZ and CCL19 as Prognostic Genes in the Cervical Cancer Micro-Environment
Authors: Zhong, Peng-Qiang; Yan, Xing-Xing
Abstract: Identification and Validation of LYZ and CCL19 as Prognostic Genes in
the Cervical Cancer Micro-Environment
Peng-Qiang Zhong1,†
, Xing-Xing Yan2,†
, Wei-Jia Wang3
, MengZhi Hong1
, Peisong Chen1,*,
Min Liu1,*
1Department of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-sen University, 510000 Guangzhou, Guangdong, China
2Traditional Chinese Medicine Hospital of Guangdong Province, Guangzhou University of Traditional Chinese Medicine, 510000 Guangzhou,
Guangdong, China
3Gynecology Department, Guangdong Women and Children Hospital, 511442 Guangzhou, Guangdong, China
*Correspondence: chps@mail3.sysu.edu.cn (Peisong Chen); luohechenzhong@foxmail.com (Min Liu)
† These authors contributed equally.
Academic Editor: Andrea Ciavattini
Submitted: 25 January 2022 Revised: 19 April 2022 Accepted: 5 May 2022 Published: 17 June 2022
Abstract
Backgrounds: Cervical cancer was a primary epithelial malignant tumor in the cervix, which was one of the most common malignant
tumor in gynecology. We aimed to investigate the relation of tumor microenvironment and the prognosis of cervical cancer patients.
Methods: We conducted an extensive bioinformatics analysis aims to study the correlation between stromal/immune cells and the prognosis of cervical cancer. In order to investigate the associations between genes and overall survival (OS) of cervical cancer. We performed
large-scale data analysis through a global gene expression profile. We analyzed the expression profile of cervical cancer using the Cancer
Genome Atlas (TCGA) database. An immune score and stromal score depending on the estimation algorithm which can quantify the
stromal or immune components of cervical cancer was obtained. Based on that, we divided the cervical cancer patients in the TCGA
database into high- and low-score groups, and then the identified different expression genes (DEGs) that expression associated with
cervical cancer patient’s prognosis was identified. After that, we generated protein-protein interaction (PPI) networks and interrelationship analyses of the immune system by performing functional enrichment analysis. Results: Our study showed that these 363 genes
were primarily associated with immune/inflammatory responses. Meanwhile, Gene Expression Omnibus (GEO) confirmed that 9 genes
(CX3CL1, SCML4, LYZ, FGD2, SLAMF6, GIMAP7, CCL19, SELP and POU2AF1) were significantly associated with cervical cancer
prognosis. Conclusions: We have made a list of genes related to tumor microenvironment which would be potential biomarkers for the
prognosis of cervical cancer patients.
Keywords: cervical cancer; OS; immune micro-environment; bioinformatics analysis2022-06-01T00:00:00ZHIPEC after Interval Debulking Surgery as Best Clinical Practice in Ovarian Cancer Patients: Case Series and Literature ReviewRestaino, StefanoMauro, Jessicahttp://localhost:8080/xmlui/handle/123456789/28712022-08-12T03:03:47Z2022-06-01T00:00:00ZTitle: HIPEC after Interval Debulking Surgery as Best Clinical Practice in Ovarian Cancer Patients: Case Series and Literature Review
Authors: Restaino, Stefano; Mauro, Jessica
Abstract: HIPEC after Interval Debulking Surgery as Best Clinical Practice in
Ovarian Cancer Patients: Case Series and Literature Review
Stefano Restaino1
, Jessica Mauro1,2
, Stefano Cianci3,*, Alessandro Buda4
,
Claudia Andreetta5
, Elena Poletto5
, Enrico Maria Pasqual6
, Alice Poli1,2
,
Cosimo Vittorio Agrimi7
, Doriana Armenise7
, Alice Buzzelli7
, Domenico Caccamo7
,
Lorenza Driul1,2
, Giuseppe Vizzielli1,2
1Clinic of Obstetrics and Gynecology, “Santa Maria della Misericordia”, University Hospital - Azienda Sanitaria Universitaria Friuli Centrale, 33100
Udine, Italy
2Department of Medical Area (DAME), University of Udine, 33100 Udine, Italy
3Department of Human Pathology of Adult and Childhood “G. Barresi”, Unit of Gynecology and Obstetrics, University of Messina, 98122 Messina,
Italy
4Division of Gynecologic Oncology, Michele e Pietro Ferrero Hospital, 12060 Verduno, Italy
5Department of Oncology, ASUFC Udine University Hospital, 33100 Udine, Italy
6Department of Medical Area, University of Udine, Santa Maria della Misericordia University Hospital Udine, 33100 Udine, Italy
7University of Udine, Department of Medical Area (DAME), Medical School, 33100 Udine, Italy
*Correspondence: stefanoc85@hotmail.it (Stefano Cianci)
Academic Editor: Samir A. Farghaly
Submitted: 17 February 2022 Revised: 15 April 2022 Accepted: 26 April 2022 Published: 16 June 2022
Abstract
Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) combined with interval debulking surgery (IDS) constitutes an adjunctive treatment strategy in advanced ovarian cancer (AOC). This approach is based on the concept of perfusing chemotherapy targeting
directly the site of residual tumor after optimal surgical debulking. It improves patients’ outcome in terms of overall survival (OS) and
disease free survival (DFS). The correct selection of patients eligible for IDS + HIPEC is crucial: in particular, they must have shown a
good response to neoadjuvant chemotherapy (NACT) and have a good performance status (PS). The application of HIPEC at the end of
debulking does not seem to increase neither the rate of intra/postoperative complications nor the time of hospitalization. Clinical Cases:
After approving an internal protocol for the application of HIPEC in our hospital, we have submitted four patients to IDS + HIPEC in
the past 12 months. One of these patients underwent a minimally invasive procedure. No intra- or postoperative complications were
observed. Results: All patients underwent IDS + HIPEC after being assessed as eligible and after showing a good response to NACT.
In the course of IDS in all cases complete debulking was achieved. No patient developed intra- or postoperative complications. Conclusions: The addition of HIPEC to interval debulking surgery should be offered to all eligible patients, considering that the association of
HIPEC to IDS seems to improve patients’ outcomes in terms of OS and DFS, without increasing post-operative morbidity .
Keywords: advanced ovarian cancer; HIPEC; interval debulking surgery2022-06-01T00:00:00ZUterine Arteries Embolization—A Rescue Tool for Acute Vaginal Bleeding in Late Stages of Gynecologic MalignanciesBohîlțea, Roxana ElenaDorobaț, Bogdanhttp://localhost:8080/xmlui/handle/123456789/28702022-08-12T03:01:41Z2022-06-01T00:00:00ZTitle: Uterine Arteries Embolization—A Rescue Tool for Acute Vaginal Bleeding in Late Stages of Gynecologic Malignancies
Authors: Bohîlțea, Roxana Elena; Dorobaț, Bogdan
Abstract: Uterine Arteries Embolization—A Rescue Tool for Acute Vaginal
Bleeding in Late Stages of Gynecologic Malignancies
Roxana Elena Bohîlțea1,2,*, Bogdan Dorobaț3
, Maria Mădalina Doldur4
, Ana-Maria Cioca4
,
Ionița Ducu5,*, Bianca Margareta Mihai2
, Corina-Aurelia Zugravu1,6
, Corina Grigoriu1,7,*,
Valentin Varlas1,2
1Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
2Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, 011171 Bucharest, Romania
3Department of Interventional Radiology, Bucharest University Emergency Hospital, 050098 Bucharest, Romania
4
“Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, 020021 Bucharest, Romania
5Department of Obstetrics and Gynecology, Life Memorial Hospital, 010719 Bucharest, Romania
6Fundamental Sciences Department, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
7Department of Obstetrics and Gynecology, Bucharest University Emergency Hospital, 050098 Bucharest, Romania
*Correspondence: dr.bohiltea@gmail.com (Roxana Elena Bohîlțea); ionitaducu@gmail.com (Ionița Ducu); corigri@gmail.com (Corina Grigoriu)
Academic Editor: Michael H. Dahan
Submitted: 26 January 2022 Revised: 18 March 2022 Accepted: 28 March 2022 Published: 15 June 2022
Abstract
Background: Uterine arteries embolization (UAE) is a minimally invasive procedure with good results when it is used as interventional
treatment for patients diagnosed with benign or malignant uterine tumors. The main gynecological malignancies that are complicated
by hemorrhages and would benefit from UAE are cervical cancer and endometrial cancer in late inoperable stages or following surgery.
Methods: During five years, in the Bucharest University Emergency Hospital’s Obstetrics and Gynecology Department, from 605
patients to whom trans-catheter embolization of the uterine arteries was performed, 33 (5.45%) were diagnosed with cervical cancer (n =
31) and endometrial cancer (n = 2) in the advanced stage addressed for heavy acute vaginal bleeding and secondary anemia. Results: For
those patients, UAE was used as palliative treatment. The average age of the patients in the evaluated group was 48.7 ± 8.3 years, and
the average number of days of hospitalization was 4.72 ± 2.97 (range 1–11). The benefits of UAE include cessation of bleeding in up to
100% of cases and expanding the window of opportunity for secondary anemia correction. The most common side effects (pain, nausea)
could be managed with mild analgesics and easily-accessible antiemetics. Conclusions: Considering these patients’ fragile advanced
oncological status, surgical ligation should be adopted only in centers where UAE is not available. The article strengthens the need for
interventional radiology departments in all regional emergency centers.
Keywords: uterine artery embolization; cervical cancer; endometrial cancer; acute uterine bleeding; palliation; heavy vaginal bleeding;
secondary anemia; mesh2022-06-01T00:00:00ZCase Report Herlyn-Werner-Wunderlich syndrome with double hematocolpos in one side hemivaginaKim, You JinYang, Jung Bohttp://localhost:8080/xmlui/handle/123456789/28692022-08-12T02:58:30Z2022-06-01T00:00:00ZTitle: Case Report Herlyn-Werner-Wunderlich syndrome with double hematocolpos in one side hemivagina
Authors: Kim, You Jin; Yang, Jung Bo
Abstract: Herlyn-Werner-Wunderlich syndrome with double hematocolpos in
one side hemivagina
You Jin Kim1,†
, Jung Bo Yang1,†
, Ye Won Jung1,†
, Soo Youn Song1
, Geon Woo Lee1
,
Heon Jong Yoo1,*
1Department of Obstetrics & Gynecology, Chungnam National University Hospital, Chungnam National University School of medicine, 282,
Munhwa-ro, 301-721 Jung-gu, Deajeon, Republic of Korea
*Correspondence: bell4184@gmail.com (Heon Jong Yoo)
†These authors contributed equally.
Academic Editor: Michael H. Dahan
Submitted: 6 February 2021 Revised: 22 February 2021 Accepted: 12 March 2021 Published: 10 June 2022
Abstract
Background: Herlyn-Werner-Wunderlich syndrome (HWWS) is an extremely rare Mullerian anomaly consisting of uterus didelphys
with obstructed hemivagina and ipsilateral renal agenesis. Although few HWWS cases had been reported in the gynecological literature,
most of the reported cases were combined with single hematocolpos. Case: We report here on a case of HWWS with double hematocolpos
on one side of a hemivagina combined with ipsilateral renal agenesis. This is the first report of HWWS with double hematocolpos on one
side of a hemivagina that was successfully treated with the resection of the vaginal septum. Conclusion: It is important to understand
the pathogenesis and clinical features of these anomalies for diagnosis.
Keywords: Hematocolpos; Hereditary renal agenesis; Urogenital abnormalities; Herlyn-Werner-Wunderlich syndrome; Mullerian
anomaly2022-06-01T00:00:00Z